Milton L. Lee
Department of Chemistry & Biochemistry
Office: C267A BNSN
Office Phone: 801-422-2135
Email: mllee@chem.byu.edu
Education
B.A. University of Utah, 1971, Chemistry
Ph.D. Indiana University, 1975, Analytical Chemistry
Research Interests
We are developing analytical separation methods for proteins based on electromobility focusing and mass spectrometry. Our main emphasis is the determination of protein cancer markers in blood for early detection of cancer.
Student Involvement/ Requirements
I can train one to two undergraduate students at a time. The undergraduates are usually put alongside graduate students to learn the techniques we use. I begin taking undergraduates in their sophomore year while they are taking Organic Chemistry. Chemistry majors and those interested in the research make more attractive candidates. Students must fill the following requirements in order to be considered for research work in my lab:
1.) Chem 105, 106, 107
2.) Willing to work a minimum of 10 hours/week for at least one year
The work is publication oriented and undergraduates do appear on the publication. The funding is generally provided by private sources or the government.
Publications
Wang, Q., Yue, B., Lee, M.L., “Mobility‑based Selective On‑line Preconcentration of Proteins in Capillary Electrophoresis by Controlling Electroosmotic Flow,” J. Chromatogr., 1025, 139 (2004).
Hawkridge, A.M., Zhou, L., Lee, M.L., Muddiman, D.C., “Analytical Performance of a Venturi Device Integrated into an Electrospray Ionization Fourier Transform Ion Cyclotron Resonance Mass Spectrometer for Analysis of Nucleic Acids,” Anal. Chem., 76, 4118 (2004).
Agbonkonkon, N., Tolley, H.D., Asplund, M.C., Lee, E.D., and Lee, M.L., “Prediction of Gas-Phase Reduced Ion Mobility Constants (K0),” Anal. Chem., 76, 5223 (2004).
Peterson, Z.D., Lee, M.L., Graves, S.W., “Determination of Serotonin and its Precursors in Human Plasma by Capillary Electrophoresis – Electrospray Ionization – Time-of-Flight Mass Spectrometry,” J. Chromatogr., 810, 101 (2004).
Humble, P.H., Kelly, R.T., Woolley, A.T., Tolley, H.D., Lee, M.L., “Electric Field Gradient Focusing of Proteins Based on Shaped Ionically Conductive Acrylic Polymer,” Anal. Chem., 76, 5641 (2004).
Liu, J., Pan, T., Woolley, A.T., Lee, M.L., “Surface-Modified Poly(methyl methacrylate) Capillary Electrophoresis Microchips for Protein and Peptide Analysis,” Anal. Chem., 76, 6948 (2004).
